To apply, simply follow these instructions–and repeat every 30 days:

Remove Applicator: Lift and remove the plastic tab to expose foil backing. Then peel away the foil. Or use scissors to open

Open Applicator: Hold upright with foil side toward you and snap applicator tip

Apply FRONTLINE: Part your dog's hair between the shoulder blades. Place the applicator tip just above the skin and squeeze. Apply entire contents of the applicator in a single spot directly onto the animal's skin. Do not apply on top of the haircoat. Avoid contact with treated area until dry

Here are some additional tips.
Remove the dog's collar
Apply as a spot between your dog's shoulder blades in 1 area that can't be licked
Avoid touching the wet application spot
Wait 48 hours to allow solution to dry before bathing or letting your dog swim
Give each of your dogs its own complete dose